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pentobarbital will minimize the level or effect of brexpiprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Double brexpiprazole dose over 1-2 weeks if administered with a robust CYP3A4 inducer.pentobarbital will lower the extent or effect of lorlatinib by influencing hepatic/intestinal enzyme C